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Silicosis

MedGen UID:
20758
•Concept ID:
C0037116
•
Disease or Syndrome
Synonyms: Accelerated silicosis; Acute silicosis; Chronic silicosis; Experimental silicosis
SNOMED CT: Silicosis (805002); Silicatosis (805002); Pneumoconiosis caused by silica (805002); Nodular silicosis (805002)
 
Monarch Initiative: MONDO:0005960

Definition

An occupational lung disorder caused by the inhalation of silica dust. It results in the inflammation and scarring of the upper lobes of the lungs. It may be an acute or chronic disorder. In the acute form, patients develop shortness of breath, fever, and cyanosis. In the chronic form patients, develop progressive shortness of breath. [from NCI]

Professional guidelines

PubMed

Early Identification, Accurate Diagnosis, and Treatment of Silicosis.
Li T, Yang X, Xu H, Liu H
Can Respir J 2022;2022:3769134. Epub 2022 Apr 25 doi: 10.1155/2022/3769134. PMID: 35509892Free PMC Article
New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis.
Adamcakova J, Mokra D
Int J Mol Sci 2021 Apr 17;22(8) doi: 10.3390/ijms22084162. PMID: 33920534Free PMC Article
Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
Getahun H, Matteelli A, Abubakar I, Aziz MA, Baddeley A, Barreira D, Den Boon S, Borroto Gutierrez SM, Bruchfeld J, Burhan E, Cavalcante S, Cedillos R, Chaisson R, Chee CB, Chesire L, Corbett E, Dara M, Denholm J, de Vries G, Falzon D, Ford N, Gale-Rowe M, Gilpin C, Girardi E, Go UY, Govindasamy D, D Grant A, Grzemska M, Harris R, Horsburgh CR Jr, Ismayilov A, Jaramillo E, Kik S, Kranzer K, Lienhardt C, LoBue P, Lönnroth K, Marks G, Menzies D, Migliori GB, Mosca D, Mukadi YD, Mwinga A, Nelson L, Nishikiori N, Oordt-Speets A, Rangaka MX, Reis A, Rotz L, Sandgren A, Sañé Schepisi M, Schünemann HJ, Sharma SK, Sotgiu G, Stagg HR, Sterling TR, Tayeb T, Uplekar M, van der Werf MJ, Vandevelde W, van Kessel F, van't Hoog A, Varma JK, Vezhnina N, Voniatis C, Vonk Noordegraaf-Schouten M, Weil D, Weyer K, Wilkinson RJ, Yoshiyama T, Zellweger JP, Raviglione M
Eur Respir J 2015 Dec;46(6):1563-76. Epub 2015 Sep 24 doi: 10.1183/13993003.01245-2015. PMID: 26405286Free PMC Article

Recent clinical studies

Etiology

Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis.
Krabbe J, Steffens KM, Drießen S, Kraus T
Eur Respir Rev 2024 Jan 31;33(171) Epub 2024 Feb 14 doi: 10.1183/16000617.0224-2023. PMID: 38355151Free PMC Article
Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.
Handra CM, Gurzu IL, Chirila M, Ghita I
Front Biosci (Landmark Ed) 2023 May 22;28(5):96. doi: 10.31083/j.fbl2805096. PMID: 37258484
Multi-omics study of silicosis reveals the potential therapeutic targets PGD(2) and TXA(2).
Pang J, Qi X, Luo Y, Li X, Shu T, Li B, Song M, Liu Y, Wei D, Chen J, Wang J, Wang C
Theranostics 2021;11(5):2381-2394. Epub 2021 Jan 1 doi: 10.7150/thno.47627. PMID: 33500731Free PMC Article
Silicosis.
Reynolds K, Jerome J
Workplace Health Saf 2021 Jan;69(1):51. Epub 2020 Nov 11 doi: 10.1177/2165079920967923. PMID: 33174526
Silica-related diseases in the modern world.
Hoy RF, Chambers DC
Allergy 2020 Nov;75(11):2805-2817. Epub 2020 Feb 15 doi: 10.1111/all.14202. PMID: 31989662

Diagnosis

Early Identification, Accurate Diagnosis, and Treatment of Silicosis.
Li T, Yang X, Xu H, Liu H
Can Respir J 2022;2022:3769134. Epub 2022 Apr 25 doi: 10.1155/2022/3769134. PMID: 35509892Free PMC Article
Silicosis: An Update and Guide for Clinicians.
Krefft S, Wolff J, Rose C
Clin Chest Med 2020 Dec;41(4):709-722. doi: 10.1016/j.ccm.2020.08.012. PMID: 33153689
Silica-related diseases in the modern world.
Hoy RF, Chambers DC
Allergy 2020 Nov;75(11):2805-2817. Epub 2020 Feb 15 doi: 10.1111/all.14202. PMID: 31989662
Silica-associated lung disease: An old-world exposure in modern industries.
Barnes H, Goh NSL, Leong TL, Hoy R
Respirology 2019 Dec;24(12):1165-1175. Epub 2019 Sep 13 doi: 10.1111/resp.13695. PMID: 31517432
Silicosis.
Leung CC, Yu IT, Chen W
Lancet 2012 May 26;379(9830):2008-18. Epub 2012 Apr 24 doi: 10.1016/S0140-6736(12)60235-9. PMID: 22534002

Therapy

Early Identification, Accurate Diagnosis, and Treatment of Silicosis.
Li T, Yang X, Xu H, Liu H
Can Respir J 2022;2022:3769134. Epub 2022 Apr 25 doi: 10.1155/2022/3769134. PMID: 35509892Free PMC Article
New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis.
Adamcakova J, Mokra D
Int J Mol Sci 2021 Apr 17;22(8) doi: 10.3390/ijms22084162. PMID: 33920534Free PMC Article
Silicosis: An Update and Guide for Clinicians.
Krefft S, Wolff J, Rose C
Clin Chest Med 2020 Dec;41(4):709-722. doi: 10.1016/j.ccm.2020.08.012. PMID: 33153689
Silica-related diseases in the modern world.
Hoy RF, Chambers DC
Allergy 2020 Nov;75(11):2805-2817. Epub 2020 Feb 15 doi: 10.1111/all.14202. PMID: 31989662
Silicosis.
Leung CC, Yu IT, Chen W
Lancet 2012 May 26;379(9830):2008-18. Epub 2012 Apr 24 doi: 10.1016/S0140-6736(12)60235-9. PMID: 22534002

Prognosis

Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis.
Krabbe J, Steffens KM, Drießen S, Kraus T
Eur Respir Rev 2024 Jan 31;33(171) Epub 2024 Feb 14 doi: 10.1183/16000617.0224-2023. PMID: 38355151Free PMC Article
Global incidence, prevalence and disease burden of silicosis: 30 years' overview and forecasted trends.
Liu X, Jiang Q, Wu P, Han L, Zhou P
BMC Public Health 2023 Jul 17;23(1):1366. doi: 10.1186/s12889-023-16295-2. PMID: 37461046Free PMC Article
Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.
Handra CM, Gurzu IL, Chirila M, Ghita I
Front Biosci (Landmark Ed) 2023 May 22;28(5):96. doi: 10.31083/j.fbl2805096. PMID: 37258484
Subradiological silicosis.
Ehrlich R, Murray J, Rees D
Am J Ind Med 2018 Nov;61(11):877-885. Epub 2018 Sep 21 doi: 10.1002/ajim.22909. PMID: 30239033
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364

Clinical prediction guides

Global incidence, prevalence and disease burden of silicosis: 30 years' overview and forecasted trends.
Liu X, Jiang Q, Wu P, Han L, Zhou P
BMC Public Health 2023 Jul 17;23(1):1366. doi: 10.1186/s12889-023-16295-2. PMID: 37461046Free PMC Article
Neutrophil Extracellular Traps and Microcrystals.
Rada B
J Immunol Res 2017;2017:2896380. Epub 2017 Mar 7 doi: 10.1155/2017/2896380. PMID: 28373994Free PMC Article
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364
Silica: a lung carcinogen.
Steenland K, Ward E
CA Cancer J Clin 2014 Jan-Feb;64(1):63-9. Epub 2013 Dec 10 doi: 10.3322/caac.21214. PMID: 24327355
Asbestosis and silicosis.
Wagner GR
Lancet 1997 May 3;349(9061):1311-5. doi: 10.1016/S0140-6736(96)07336-9. PMID: 9142077

Recent systematic reviews

TB and interstitial lung disease: a systematic review and meta-analysis.
Rezaee M, Azizi N, Danaei B, Davari A, Nejadghaderi SA, Sarmastzadeh T, Rahmannia M, Khalili F, Shahidi-Bonjar AH, Centis R, D'Ambrosio L, Sotgiu G, Migliori GB, Nasiri MJ
Int J Tuberc Lung Dis 2024 Mar 1;28(3):130-135. doi: 10.5588/ijtld.23.0428. PMID: 38454180
Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis.
Krabbe J, Steffens KM, Drießen S, Kraus T
Eur Respir Rev 2024 Jan 31;33(171) Epub 2024 Feb 14 doi: 10.1183/16000617.0224-2023. PMID: 38355151Free PMC Article
Genetic susceptibility in pneumoconiosis in China: a systematic review.
Chair SY, Chan JYW, Law BMH, Waye MMY, Chien WT
Int Arch Occup Environ Health 2023 Jan;96(1):45-56. Epub 2022 Jul 29 doi: 10.1007/s00420-022-01893-1. PMID: 35906431
The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis.
Ehrlich R, Akugizibwe P, Siegfried N, Rees D
BMC Public Health 2021 May 20;21(1):953. doi: 10.1186/s12889-021-10711-1. PMID: 34016067Free PMC Article
Laryngeal cancer and silica dust exposure: a systematic review and meta-analysis.
Chen M, Tse LA
Am J Ind Med 2012 Aug;55(8):669-76. Epub 2012 Mar 27 doi: 10.1002/ajim.22037. PMID: 22457229

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